Scientific Studies on Wonderful Variety Pomegranates

There are several varieties of pomegranates grown in various locations throughout the world. The
following research was conducted exclusively with California grown, Wonderful variety Pomegranates.

Subjects received a minimum of eight ounces of POM Wonderful 100% Pomegranate Juice or
850mg POMx pomegranate polyphenol extract per day.

Close [x]

Search Published Studies

Year

Study Topic

Study Author

View All Studies

Bioavailability

Pomegranate Juice and Extracts Provide Similar Levels of Plasma and Urinary Ellagitannin Metabolites in Human Subjects

by NP Seeram, et al.

Journal of Medicinal Food, 2008

Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours

by NP Seeram, et al.

The Journal of Nutrition, 2006

Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice

by NP Seeram, et al.

Clinica Chimica Acta, 2004

Cancer

Non-Prostate

Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro

by LS Adams, et al.

Cancer Prevention Research, 2010

Photochemopreventive Effect of Pomegranate Fruit Extract on UVA-mediated Activation of Cellular Pathways in Normal Human Epidermal Keratinocytes

by DN Syed, et al.

Photochemistry and Photobiology, 2006

Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells

by LS Adams, et al.

Journal of Agricultural and Food Chemistry, 2006

In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice

by NP Seeram, et al.

Journal of Nutritional Biochemistry, 2005

Prostate

Effects of Pomegranate Chemical Constituents/Intestinal Microbial Metabolites on CYP1B1 in 22Rv1 Prostate Cancer Cells

by SG Kasimetty, et al.

Journal of Agriculture and Food Chemistry, 2009

Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor

by MY Hong, et al.

Journal of Nutritional Biochemistry, 2008

Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-κB-dependent mechanism

by MB Rettig, et al.

Molecular Cancer Therapy, 2008

Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo

by MR Sartippour, et al.

International Journal of Oncology, 2008

Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland

by NP Seeram, et al.

Journal of Agricultural and Food Chemistry, 2007

Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer

by AJ Pantuck, et al.

Clinical Cancer Research, 2006

Cardiovascular

Arterial Plaque

Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: Studies in vitro and in diabetic patients

by B Fuhrman, et al.

Nutrition, 2010

Effects of Consumption of Pomegranate Juice on Carotid Intima-Media Thickness in Men and Women at Moderate Risk for Coronary Heart Disease

by MH Davidson, et al.

American Journal of Cardiology, 2009

Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: A role for PPAR-γ pathway

by J Khateeb, et al.

Atherosclerosis, 2009

Pomegranate Phenolics from the Peels, Arils, and Flowers Are Antiatherogenic: Studies in Vivo in Atherosclerotic Apolipoprotein E-Deficient (E0) Mice and in Vitro in Cultured Macrophages and Lipoproteins

by M Aviram, et al.

Journal of Agricultural and Food Chemistry, 2008

Effects of a Pomegranate Fruit Extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis

by F de Nigris, et al.

Cardiovascular Research, 2007

Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR-γ and AP-1 pathway activation

by M Shiner, et al.

Atherosclerosis, 2007

The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats

by F de Nigiris, et al.

Nitric Oxide, 2007

Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells

by F de Nigris, et al.

Nitric Oxide, 2006

Pomegranate Byproduct Administration to Apolipoprotein E-Deficient Mice Attenuates Atherosclerosis Development as a Result of Decreased Macrophage Oxidative Stress and Reduced Cellular Uptake of Oxidized Low-Density Lipoprotein

by M Rosenblat, et al.

Journal of Agricultural and Food Chemistry, 2006

Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide

by LJ Ignarro, et al.

Nitric Oxide, 2006

Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it

by O Rozenberg, et al.

Atherosclerosis, 2006

Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress

by F de Nigris, et al.

Proceedings of the National Academy of Sciences, 2005

Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages

by B Fuhrman, et al.

Journal of Nutritional Biochemistry, 2005

Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness and LDL oxidation

by M Aviram, et al.

Clinical Nutrition, 2004

Pomegranate Juice Supplementation to Atherosclerotic Mice Reduces Macrophage Lipid Peroxidation, Cellular Cholesterol Accumulation and Development of Atherosclerosis

by M Kaplan, et al.

Journal of Nutrition, 2001

Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E–deficient mice

by M Aviram, et al.

American Journal of Clinical Nutrition, 2000

Blood Flow

Effects of Pomegranate Juice Consumption on Myocardial Perfusion in Patients With Coronary Heart Disease

by MD Sumner, et al.

American Journal of Cardiology, 2005

Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity

by M Aviram, et al.

Atherosclerosis, 2001

Other

Pomegranate Juice Protects Macrophages from Triglyceride Accumulation: Inhibitory Effect on DGAT1 Activity and on Triglyceride Biosynthesis

by M. Rosenblat, et al.

Annals of Nutrition and Metabolism, 2011

Effects of Pomegranate Juice and Extract Polyphenols on Platelet Function

by T Mattiello, et al.

Journal of Medicinal Food, 2009

Cognitive Function

Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer’s disease

by RE Hartman, et al.

Neurobiology of Disease, 2006

Maternal Dietary Supplementation with Pomegranate Juice Is Neuroprotective in an Animal Model of Neonatal Hypoxic-Ischemic Brain Injury

by DJ Loren, et al.

Pediatric Research, 2005

Composition

Antioxidants

Comparison of the polyphenolic composition and antioxidant activity of European commercial fruit juices

by G Borges, et al.

Food & Function, 2010

Consumption of polyphenolic-rich beverages (mostly pomegranate and black currant juices) by healthy subjects for a short term increased serum antioxidant status, and the serum’s ability to attenuate macrophage cholesterol accumulation

by M Rosenblat, et al.

Food & Function, 2010

Absence of Pomegranate Ellagitannins in the Majority of Commercial Pomegranate Extracts: Implications for Standardization and Quality Control

by Y Zhang, et al.

Journal of Agricultural and Food Chemistry, 2009

Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay

by D Bialonska, et al.

Journal of Agriculture and Food Chemistry, 2009

Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich Beverages in the United States

by NP Seeram, et al.

Journal of Agricultural and Food Chemistry, 2008

Antioxidant Activity of Pomegranate Juice and Its Relationship with Phenolic Composition and Processing

by MI Gil, et al.

Journal of Agricultural and Food Chemistry, 2000

Authenticity

Pomegranate (Punica granatum) supplements: Authenticity, antioxidant and polyphenol composition

by S Madrigal-Carballo, et al.

Journal of Functional Foods, 2009

International Multidimensional Authenticity Specification (IMAS) Algorithm for Detection of Commercial Pomegranate Juice Adulteration

by Y Zhang, et al.

Journal of Agricultural and Food Chemistry, 2009

Polyphenols

Development of a novel pomegranate standard and new method for the quantitative measurement of pomegranate polyphenols

by KR Martin et al.

Journal of the Science of Food and Agriculture, 2009

Immunity

Cold/Flu

Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins

by A Sundararajan, et al.

Antiviral Research, 2010

Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir

by M Haidari, et al.

Phytomedicine, 2009

Other

Effects of feeding polyphenols from pomegranate extract on health, growth, nutrient digestion, and immunocompetence of calves

by RA Oliveira, et al.

Journal of Dairy Science, 2010

The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota

by D Bialonska, et al.

International Journal of Food Microbiology, 2010

The Effect of Pomegranate (Punica granatum L.) Byproducts and Ellagitannins on the Growth of Human Gut Bacteria

by D Bialonska, et al.

Journal of Agriculture and Food Chemistry, 2009

Antioxidant, Antimalarial and Antimicrobial Activities of Tannin-Rich Fractions, Ellagitannins and Phenolic Acids from Punica granatum L.

by MK Reddy, et al.

Planta Medica, 2007

Inflammatory Disorders

Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells

by Z Rasheed, et al.

Journal of Inflammation, 2009

Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis

by M Shukla, et al.

Nutrition, 2008

Metabolism

Diabetes Type II

A Study to Measure the Glycaemic Index Value of Pomegranate Juice

by Glycaemic Index Research Service, School of Molecular & Microbial Biosciences, Sydney University

Glycaemic Index Research Report, 2009

Consumption of Wonderful Variety Pomegranate Juice and Extract by Diabetic Patients Increases Paraoxonase 1 Association with High-Density Lipoprotein and Stimulates Its Catalytic Activities

by W Rock, et al.

Journal of Agricultural and Food Chemistry, 2008

Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice

by BK McFarlin, et al.

British Journal of Nutrition, 2008

Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages

by M Rosenblat, et al.

Atherosclerosis, 2006

Reproductive

Erectile Dysfunction

Dietary antioxidants improve arteriogenic erectile dysfunction

by Q Zhang, et al.

International Journal of Andrology, 2010

Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study

by CP Forest, et al.

International Journal of Impotence Research, 2007

Oxidative Stress in Arteriogenic Erectile Dysfunction: Prophylactic Role of Antioxidants

by KM Azadzoi

The Journal of Urology, 2005

Review Articles

The effects of pomegranate juice consumption on cardiovascular health

by CB Stowe

Complementary Therapies in Clinical Practice, 2011

Scientific and Clinical Monograph for POM Wonderful Pomegranate Juice

by A McCutcheon, et al.

American Botanical Council, 2008

Pomegranates and Prostate Health: Research Report

by M Dreher

PCRI Insights, 2008

Polyphenols from green tea and pomegranate for prevention of prostate cancer

by VM Adhami, et al.

Free Radical Research, 2006

Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: Studies in atherosclerotic mice and in humans

by AM Dornfeld

Drugs Under Experimental and Clinical Research, 2002

Safety

Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam, a Probe for Cytochrome P450-3A Activity: Comparison With Grapefruit Juice

by D Farkas, et al.

The Journal of Clinical Pharmacology, 2007

Safety and Antioxidant Activity of a Pomegranate Ellagitannin-Enriched Polyphenol Dietary Supplement in Overweight Individuals with Increased Waist Size

by D Heber, et al.

Journal of Agricultural and Food Chemistry, 2007

Absence of Significant Estrogenic Effects in the Postmenopausal Population

by MP Warren, et al.

Pomegranates: Ancient Roots to Modern Medicine
ed: NP Seeram, et al. (Boca Raton: CRC Press), pp.157-166., 2006

Skin Care

Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin

by F Afaq, et al.

Experimental Dermatology, 2008

Inhibition of UVB-mediated Oxidative Stress and Markers of Photoaging in Immortalized HaCaT Keratinocytes by Pomegranate Polyphenol Extract POMx

by MA Zaid, et al.

Photochemistry and Photobiology, 2007

Sports Physiology

Ellagitannin Consumption Improves Strength Recovery 2-3 d after Eccentric Exercise

by JR Trombold, et al.

Medicine & Science in Sports & Excercise, 2010